Drug interactions
Ethinyl estradiol-drospirenone + Ketorolac
Severity: Moderate
Ethinyl estradiol-drospirenone and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can impair renal potassium excretion and reduce renal function, and drospirenone adds anti-mineralocorticoid potassium retention. Hyperkalemia is possible, particularly with prolonged use or kidney impairment.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive potassium retention from NSAID-induced reduction in renin-aldosterone activity and drospirenone aldosterone antagonism.
What to do
Keep ketorolac courses short and check serum potassium and renal function if use is prolonged or renal risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Ketorolac?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac can impair renal potassium excretion and reduce renal function, and drospirenone adds anti-mineralocorticoid potassium retention. Hyperkalemia is possible, particularly with prolonged use or kidney impairment.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac courses short and check serum potassium and renal function if use is prolonged or renal risk factors exist.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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