Drug interactions
Ethinyl estradiol-drospirenone + Levalbuterol
Severity: Minor
Ethinyl estradiol-drospirenone and Levalbuterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone tends to raise potassium while levalbuterol, a beta-2 agonist, shifts potassium into cells and can lower serum levels. The effects partly oppose one another and no clinically meaningful problem is expected at usual doses. Higher or repeated levalbuterol doses can cause hypokalemia regardless of the contraceptive.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Levalbuterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on serum potassium: drospirenone antimineralocorticoid retention versus beta-2 mediated intracellular potassium shift.
What to do
No routine action is needed at standard doses. Check potassium if high-dose or frequent levalbuterol is used, or in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Levalbuterol?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Levalbuterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone tends to raise potassium while levalbuterol, a beta-2 agonist, shifts potassium into cells and can lower serum levels. The effects partly oppose one another and no clinically meaningful problem is expected at usual doses. Higher or repeated levalbuterol doses can cause hypokalemia regardless of the contraceptive.
How serious is the interaction between Ethinyl estradiol-drospirenone and Levalbuterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed at standard doses. Check potassium if high-dose or frequent levalbuterol is used, or in patients with renal impairment.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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