Drug interactions
Ethinyl estradiol-drospirenone + Meclofenamate
Severity: Moderate
Ethinyl estradiol-drospirenone and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise serum potassium and NSAIDs such as meclofenamate can impair renal potassium excretion. The combination may add to the risk of hyperkalemia, especially with renal impairment, diabetes or other potassium-raising drugs.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyperkalemia from drospirenone's aldosterone antagonism and NSAID-induced reduction in renal prostaglandins and renin-aldosterone activity.
What to do
Check serum potassium in the first cycle when long-term NSAID therapy is started with this contraceptive. Pay particular attention in patients with renal impairment or on other potassium-raising drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Meclofenamate?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone can raise serum potassium and NSAIDs such as meclofenamate can impair renal potassium excretion. The combination may add to the risk of hyperkalemia, especially with renal impairment, diabetes or other potassium-raising drugs.
How serious is the interaction between Ethinyl estradiol-drospirenone and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle when long-term NSAID therapy is started with this contraceptive. Pay particular attention in patients with renal impairment or on other potassium-raising drugs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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