Drug interactions
Ethinyl estradiol-drospirenone + Methyclothiazide
Severity: Minor
Ethinyl estradiol-drospirenone and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise potassium while thiazide diuretics such as methyclothiazide lower it through renal loss. The effects partly offset each other, so net potassium change is unpredictable but usually small. Thiazides may also mildly affect blood pressure alongside the contraceptive.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on potassium: drospirenone antimineralocorticoid potassium retention versus thiazide-induced renal potassium wasting.
What to do
No dose change is usually needed. Check serum potassium and blood pressure periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Methyclothiazide?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone can raise potassium while thiazide diuretics such as methyclothiazide lower it through renal loss. The effects partly offset each other, so net potassium change is unpredictable but usually small. Thiazides may also mildly affect blood pressure alongside the contraceptive.
How serious is the interaction between Ethinyl estradiol-drospirenone and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Check serum potassium and blood pressure periodically.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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