Drug interactions
Ethinyl estradiol-drospirenone + Mycophenolate
Severity: Major
Ethinyl estradiol-drospirenone and Mycophenolate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate labeling reports that hormonal contraceptive levels may be affected, and mycophenolate is teratogenic, so contraceptive failure is a serious concern. Pharmacokinetic effects appear limited but contraception reliability is critical.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mechanism is not firmly established; possible small effects on progestin exposure.
What to do
Add or use an additional contraceptive method such as condoms or an intrauterine device during therapy. Follow mycophenolate pregnancy prevention requirements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Mycophenolate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Mycophenolate?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mycophenolate labeling reports that hormonal contraceptive levels may be affected, and mycophenolate is teratogenic, so contraceptive failure is a serious concern. Pharmacokinetic effects appear limited but contraception reliability is critical.
How serious is the interaction between Ethinyl estradiol-drospirenone and Mycophenolate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add or use an additional contraceptive method such as condoms or an intrauterine device during therapy. Follow mycophenolate pregnancy prevention requirements.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
