Drug interactions
Ethinyl estradiol-drospirenone + Neomycin po
Severity: Minor
Ethinyl estradiol-drospirenone and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin alters gut flora and was theorised to reduce enterohepatic recycling of estrogen. Documented contraceptive failure is rare and the evidence is weak.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Suppression of intestinal bacteria is proposed to reduce hydrolysis of estrogen conjugates and their enterohepatic recirculation; the clinical significance is unproven.
What to do
No routine change is needed. Advise the patient to use backup contraception if severe vomiting or diarrhea occurs or if doses are missed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Neomycin po, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Neomycin po?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin alters gut flora and was theorised to reduce enterohepatic recycling of estrogen. Documented contraceptive failure is rare and the evidence is weak.
How serious is the interaction between Ethinyl estradiol-drospirenone and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise the patient to use backup contraception if severe vomiting or diarrhea occurs or if doses are missed.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
