Drug interactions
Ethinyl estradiol-drospirenone + Olmesartan
Severity: Moderate
Ethinyl estradiol-drospirenone and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan blocks angiotensin II receptors and lowers aldosterone effect, while drospirenone is anti-mineralocorticoid. Together they can raise serum potassium, particularly in renal impairment or diabetes.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
Additive potassium retention via angiotensin receptor blockade and drospirenone aldosterone antagonism.
What to do
Measure serum potassium during the first cycle and periodically afterwards. Use a non-drospirenone contraceptive if potassium is high at baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Olmesartan?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan blocks angiotensin II receptors and lowers aldosterone effect, while drospirenone is anti-mineralocorticoid. Together they can raise serum potassium, particularly in renal impairment or diabetes.
How serious is the interaction between Ethinyl estradiol-drospirenone and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first cycle and periodically afterwards. Use a non-drospirenone contraceptive if potassium is high at baseline.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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