Drug interactions
Ethinyl estradiol-drospirenone + Parecoxib
Severity: Minor
Ethinyl estradiol-drospirenone and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise potassium and COX-2 inhibitors such as parecoxib can reduce renal potassium excretion. The combination may add to hyperkalemia risk, particularly in renal impairment. Parecoxib is typically used briefly after surgery.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hyperkalemia from drospirenone aldosterone antagonism and NSAID-related suppression of renal prostaglandins and renin.
What to do
No action is usually needed for short courses. Check potassium if renal impairment is present or therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Parecoxib?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone can raise potassium and COX-2 inhibitors such as parecoxib can reduce renal potassium excretion. The combination may add to hyperkalemia risk, particularly in renal impairment. Parecoxib is typically used briefly after surgery.
How serious is the interaction between Ethinyl estradiol-drospirenone and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed for short courses. Check potassium if renal impairment is present or therapy is prolonged.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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