Drug interactions
Ethinyl estradiol-drospirenone + Penicillin vk
Severity: Minor
Ethinyl estradiol-drospirenone and Penicillin vk: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral penicillin V was theorised to reduce estrogen levels by altering gut flora, but studies have not shown reduced contraceptive efficacy. The risk is considered very low.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed reduction in enterohepatic recycling of ethinyl estradiol through gut flora changes; not clinically demonstrated.
What to do
No additional contraception is routinely required. Advise backup methods only if vomiting, diarrhea or missed pills occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Penicillin vk?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral penicillin V was theorised to reduce estrogen levels by altering gut flora, but studies have not shown reduced contraceptive efficacy. The risk is considered very low.
How serious is the interaction between Ethinyl estradiol-drospirenone and Penicillin vk?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is routinely required. Advise backup methods only if vomiting, diarrhea or missed pills occur.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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