Drug interactions
Ethinyl estradiol-drospirenone + Perindopril
Severity: Moderate
Ethinyl estradiol-drospirenone and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has potassium-sparing antimineralocorticoid activity, and ACE inhibitors lower aldosterone. Combined use can raise serum potassium and may cause hyperkalemia, particularly in patients with renal impairment.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
Additive potassium retention from drospirenone's aldosterone antagonism and ACE inhibitor suppression of aldosterone.
What to do
Check serum potassium during the first treatment cycle and periodically afterwards, and choose a non-drospirenone contraceptive if potassium rises or renal function is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Perindopril?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has potassium-sparing antimineralocorticoid activity, and ACE inhibitors lower aldosterone. Combined use can raise serum potassium and may cause hyperkalemia, particularly in patients with renal impairment.
How serious is the interaction between Ethinyl estradiol-drospirenone and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle and periodically afterwards, and choose a non-drospirenone contraceptive if potassium rises or renal function is poor.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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