Drug interactions
Ethinyl estradiol-drospirenone + Potassium citrate / citric acid
Severity: Moderate
Ethinyl estradiol-drospirenone and Potassium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium citrate supplies potassium, and drospirenone reduces renal potassium excretion through anti-mineralocorticoid action. Together they can cause hyperkalemia, especially with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium load plus aldosterone antagonism by drospirenone.
What to do
Check serum potassium in the first cycle of combined use and periodically afterwards. Consider a contraceptive without drospirenone in patients at high risk of hyperkalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Potassium citrate / citric acid?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium citrate supplies potassium, and drospirenone reduces renal potassium excretion through anti-mineralocorticoid action. Together they can cause hyperkalemia, especially with renal impairment or other potassium-raising drugs.
How serious is the interaction between Ethinyl estradiol-drospirenone and Potassium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle of combined use and periodically afterwards. Consider a contraceptive without drospirenone in patients at high risk of hyperkalemia.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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