Drug interactions
Ethinyl estradiol-drospirenone + Quinupristin / dalfopristin
Severity: Minor
Ethinyl estradiol-drospirenone and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise concentrations of CYP3A4-metabolised drugs, including ethinyl estradiol and drospirenone. The clinical effect is likely small and mostly increased estrogenic or hormonal adverse effects.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal and hepatic CYP3A4 reduces hormone clearance.
What to do
No dose change is generally needed. Watch for increased estrogenic adverse effects or elevated potassium during a short course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and may raise concentrations of CYP3A4-metabolised drugs, including ethinyl estradiol and drospirenone. The clinical effect is likely small and mostly increased estrogenic or hormonal adverse effects.
How serious is the interaction between Ethinyl estradiol-drospirenone and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Watch for increased estrogenic adverse effects or elevated potassium during a short course.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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