Drug interactions
Ethinyl estradiol-drospirenone + Selegiline transdermal
Severity: Moderate
Ethinyl estradiol-drospirenone and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives can raise selegiline concentrations by reducing its metabolism. Higher exposure may increase MAO inhibitor effects such as blood pressure changes and loss of MAO-B selectivity.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinyl estradiol inhibits hepatic oxidative metabolism of selegiline, increasing its levels.
What to do
Monitor blood pressure and for adverse effects of selegiline, and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Selegiline transdermal?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives can raise selegiline concentrations by reducing its metabolism. Higher exposure may increase MAO inhibitor effects such as blood pressure changes and loss of MAO-B selectivity.
How serious is the interaction between Ethinyl estradiol-drospirenone and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for adverse effects of selegiline, and reduce the dose if they occur.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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