Drug interactions
Ethinyl estradiol-drospirenone + Sulfamethoxazole
Severity: Minor
Ethinyl estradiol-drospirenone and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole is not an enzyme inducer, and no consistent evidence shows reduced contraceptive efficacy. The risk is theoretical.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed gut flora effect on estrogen recycling; unproven.
What to do
No additional contraception is needed. Apply standard missed-pill and gastrointestinal illness advice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Sulfamethoxazole?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole is not an enzyme inducer, and no consistent evidence shows reduced contraceptive efficacy. The risk is theoretical.
How serious is the interaction between Ethinyl estradiol-drospirenone and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is needed. Apply standard missed-pill and gastrointestinal illness advice.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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