Drug interactions
Ethinyl estradiol-drospirenone + Telmisartan
Severity: Moderate
Ethinyl estradiol-drospirenone and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan lowers aldosterone effect through angiotensin receptor blockade, and drospirenone is anti-mineralocorticoid. Together they can cause hyperkalemia, particularly in renal impairment or diabetes.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Telmisartan belongs to Cardiovascular.
Why it happens
Additive potassium retention via angiotensin receptor blockade and drospirenone aldosterone antagonism.
What to do
Measure serum potassium during the first cycle and periodically thereafter. Use a non-drospirenone contraceptive if baseline potassium is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Telmisartan?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan lowers aldosterone effect through angiotensin receptor blockade, and drospirenone is anti-mineralocorticoid. Together they can cause hyperkalemia, particularly in renal impairment or diabetes.
How serious is the interaction between Ethinyl estradiol-drospirenone and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first cycle and periodically thereafter. Use a non-drospirenone contraceptive if baseline potassium is high.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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