Drug interactions
Ethinyl estradiol-drospirenone + Valoctocogene roxaparvovec
Severity: Moderate
Ethinyl estradiol-drospirenone and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes elevated liver enzymes, and hepatotoxic medicines may add to this risk. Combined hormonal contraceptives are metabolized by the liver and can occasionally cause liver enzyme elevation. Distinguishing the cause of a transaminase rise can be difficult.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxic potential; gene therapy-related hepatocellular injury may be compounded by hormonal agents.
What to do
Monitor ALT and other liver tests regularly after gene therapy, as per the product labeling. Consider a non-hormonal contraceptive if persistent enzyme elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes elevated liver enzymes, and hepatotoxic medicines may add to this risk. Combined hormonal contraceptives are metabolized by the liver and can occasionally cause liver enzyme elevation. Distinguishing the cause of a transaminase rise can be difficult.
How serious is the interaction between Ethinyl estradiol-drospirenone and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT and other liver tests regularly after gene therapy, as per the product labeling. Consider a non-hormonal contraceptive if persistent enzyme elevations occur.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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