Drug interactions
Ethinyl estradiol-levonorgestrel + Flibanserin
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives are weak CYP3A4 inhibitors and may raise flibanserin levels, increasing the risk of hypotension, syncope and sedation. Flibanserin labeling cautions about use with multiple weak CYP3A4 inhibitors, and oral contraceptives are commonly used together with it.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Flibanserin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4-mediated flibanserin metabolism by ethinyl estradiol.
What to do
Counsel the patient on dizziness, hypotension and syncope, and avoid alcohol close to the dose. Consider reevaluation if other CYP3A4 inhibitors are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Flibanserin?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives are weak CYP3A4 inhibitors and may raise flibanserin levels, increasing the risk of hypotension, syncope and sedation. Flibanserin labeling cautions about use with multiple weak CYP3A4 inhibitors, and oral contraceptives are commonly used together with it.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on dizziness, hypotension and syncope, and avoid alcohol close to the dose. Consider reevaluation if other CYP3A4 inhibitors are added.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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