Drug interactions
Ethinyl estradiol-levonorgestrel + Fluvoxamine
Severity: Minor
Ethinyl estradiol-levonorgestrel and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol may increase fluvoxamine concentrations, although the effect is probably small. Fluvoxamine may in turn alter estrogen metabolism, with unclear significance.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Fluvoxamine belongs to Central Nervous System.
Why it happens
Possible CYP1A2 inhibition by ethinyl estradiol slightly reducing fluvoxamine clearance.
What to do
No routine action is needed; monitor for fluvoxamine adverse effects such as nausea and sedation and adjust the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Fluvoxamine?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol may increase fluvoxamine concentrations, although the effect is probably small. Fluvoxamine may in turn alter estrogen metabolism, with unclear significance.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for fluvoxamine adverse effects such as nausea and sedation and adjust the dose if they occur.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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