Drug interactions
Ethinyl estradiol-levonorgestrel + Lixisenatide
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide slows gastric emptying and may reduce the rate and extent of oral contraceptive absorption. Contraceptive efficacy could be affected if levels fall.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
Delayed gastric emptying from lixisenatide reduces and delays absorption of oral drugs.
What to do
Take the oral contraceptive at least 1 hour before lixisenatide injection or at least 11 hours after. Counsel the patient on the importance of consistent timing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Lixisenatide
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Lixisenatide?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide slows gastric emptying and may reduce the rate and extent of oral contraceptive absorption. Contraceptive efficacy could be affected if levels fall.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least 1 hour before lixisenatide injection or at least 11 hours after. Counsel the patient on the importance of consistent timing.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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