Drug interactions
Glimepiride + Lixisenatide
Severity: Moderate
Glimepiride and Lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide enhances glucose-dependent insulin secretion, and combined with a sulfonylurea it increases hypoglycemia risk. Lower sulfonylurea doses are often needed.
What this interaction means in plain words
Glimepiride and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
Additive insulinotropic effects of GLP-1 receptor agonism and sulfonylurea action.
What to do
Consider reducing the glimepiride dose when lixisenatide is started. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Lixisenatide
Frequently asked questions
Can I take Glimepiride with Lixisenatide?
MediHelp rates the interaction as moderate. Glimepiride and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide enhances glucose-dependent insulin secretion, and combined with a sulfonylurea it increases hypoglycemia risk. Lower sulfonylurea doses are often needed.
How serious is the interaction between Glimepiride and Lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when lixisenatide is started. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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