Drug interactions
Desogestrel-ethinyl estradiol + Lixisenatide
Severity: Moderate
Desogestrel-ethinyl estradiol and Lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide slows gastric emptying and can delay or reduce absorption of oral drugs. This may lower peak concentrations of oral contraceptive hormones and potentially reduce efficacy.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
Delayed gastric emptying by lixisenatide alters oral absorption of contraceptive hormones.
What to do
Take the oral contraceptive at least 1 hour before or 11 hours after lixisenatide. Counsel about contraceptive backup if vomiting or diarrhea occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Lixisenatide
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Lixisenatide?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide slows gastric emptying and can delay or reduce absorption of oral drugs. This may lower peak concentrations of oral contraceptive hormones and potentially reduce efficacy.
How serious is the interaction between Desogestrel-ethinyl estradiol and Lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least 1 hour before or 11 hours after lixisenatide. Counsel about contraceptive backup if vomiting or diarrhea occurs.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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