Drug interactions
Gliclazide + Lixisenatide
Severity: Moderate
Gliclazide and Lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide increases the risk of hypoglycemia when used with sulfonylureas like gliclazide. The risk is highest when starting treatment.
What this interaction means in plain words
Gliclazide and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
GLP-1 receptor agonism enhances glucose-dependent insulin secretion, adding to sulfonylurea effects.
What to do
Reduce the gliclazide dose when starting lixisenatide, and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Lixisenatide
Frequently asked questions
Can I take Gliclazide with Lixisenatide?
MediHelp rates the interaction as moderate. Gliclazide and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide increases the risk of hypoglycemia when used with sulfonylureas like gliclazide. The risk is highest when starting treatment.
How serious is the interaction between Gliclazide and Lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the gliclazide dose when starting lixisenatide, and monitor blood glucose.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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