Drug interactions
Ethinyl estradiol-levonorgestrel + Lomitapide
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and may raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal effects. Labeling limits the lomitapide dose in patients using weak CYP3A4 inhibitors such as oral contraceptives.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Lomitapide belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition reduces lomitapide metabolism, increasing its plasma concentration.
What to do
Limit the lomitapide dose per labeling and monitor liver enzymes and gastrointestinal tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Lomitapide?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol is a weak CYP3A4 inhibitor and may raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal effects. Labeling limits the lomitapide dose in patients using weak CYP3A4 inhibitors such as oral contraceptives.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose per labeling and monitor liver enzymes and gastrointestinal tolerability.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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