Drug interactions
Ethinyl estradiol-levonorgestrel + Siltuximab
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Siltuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siltuximab blocks IL-6, which can reverse the cytokine-mediated suppression of CYP450 enzymes. Metabolism of CYP substrates such as ethinyl estradiol and levonorgestrel may therefore increase, possibly lowering their concentrations and efficacy.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Siltuximab belongs to Miscellaneous.
Why it happens
IL-6 inhibition restores CYP3A4 and other CYP450 expression, increasing clearance of substrate drugs.
What to do
Advise additional non-hormonal contraception during and for several weeks after siltuximab. Monitor for breakthrough bleeding or loss of contraceptive effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-norgestimate + Siltuximab Moderate
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Siltuximab?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siltuximab blocks IL-6, which can reverse the cytokine-mediated suppression of CYP450 enzymes. Metabolism of CYP substrates such as ethinyl estradiol and levonorgestrel may therefore increase, possibly lowering their concentrations and efficacy.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Siltuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise additional non-hormonal contraception during and for several weeks after siltuximab. Monitor for breakthrough bleeding or loss of contraceptive effect.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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