Drug interactions
Cyclosporin + Siltuximab
Severity: Moderate
Cyclosporin and Siltuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interleukin-6 suppresses hepatic CYP450 expression during inflammation. Blocking IL-6 with siltuximab may restore enzyme activity and lower cyclosporine concentrations, which could reduce immunosuppression.
What this interaction means in plain words
Cyclosporin and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Siltuximab belongs to Miscellaneous.
Why it happens
Siltuximab neutralizes IL-6, reversing cytokine-mediated downregulation of CYP3A4 and increasing cyclosporine metabolism.
What to do
Monitor cyclosporine trough concentrations when siltuximab is started or stopped. Adjust the cyclosporine dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Siltuximab
Frequently asked questions
Can I take Cyclosporin with Siltuximab?
MediHelp rates the interaction as moderate. Cyclosporin and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interleukin-6 suppresses hepatic CYP450 expression during inflammation. Blocking IL-6 with siltuximab may restore enzyme activity and lower cyclosporine concentrations, which could reduce immunosuppression.
How serious is the interaction between Cyclosporin and Siltuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations when siltuximab is started or stopped. Adjust the cyclosporine dose according to levels and clinical response.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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