Drug interactions
Baricitinib + Siltuximab
Severity: Major
Baricitinib and Siltuximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs interfere with immune and cytokine signaling, so using them together may increase the risk of serious infection. Baricitinib is not recommended with biologic immunomodulators.
What this interaction means in plain words
Baricitinib and Siltuximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Siltuximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from JAK inhibition and interleukin-6 blockade.
What to do
Avoid combined use. If unavoidable, monitor closely for infection, noting that siltuximab can mask fever and CRP elevation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Siltuximab
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
- Ethinyl estradiol-norgestimate + Siltuximab Moderate
Frequently asked questions
Can I take Baricitinib with Siltuximab?
MediHelp rates the interaction as major. Baricitinib and Siltuximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs interfere with immune and cytokine signaling, so using them together may increase the risk of serious infection. Baricitinib is not recommended with biologic immunomodulators.
How serious is the interaction between Baricitinib and Siltuximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use. If unavoidable, monitor closely for infection, noting that siltuximab can mask fever and CRP elevation.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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