Drug interactions
Carbamazepine + Siltuximab
Severity: Moderate
Carbamazepine and Siltuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-6 can reverse cytokine-mediated suppression of CYP enzymes, raising metabolism of CYP substrates. Carbamazepine concentrations may fall, with a narrow therapeutic index.
What this interaction means in plain words
Carbamazepine and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Siltuximab belongs to Miscellaneous.
Why it happens
IL-6 neutralization restores CYP450 (including CYP3A4) activity, increasing carbamazepine clearance.
What to do
Monitor carbamazepine concentrations and clinical response when siltuximab is started or stopped, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
- Ethinyl estradiol-norgestimate + Siltuximab Moderate
Frequently asked questions
Can I take Carbamazepine with Siltuximab?
MediHelp rates the interaction as moderate. Carbamazepine and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blocking IL-6 can reverse cytokine-mediated suppression of CYP enzymes, raising metabolism of CYP substrates. Carbamazepine concentrations may fall, with a narrow therapeutic index.
How serious is the interaction between Carbamazepine and Siltuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine concentrations and clinical response when siltuximab is started or stopped, adjusting the dose as needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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