Drug interactions
Maraviroc + Tecovirimat
Severity: Moderate
Maraviroc and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat may reduce maraviroc exposure, possibly weakening antiretroviral control. The effect is predicted from enzyme induction rather than established clinically.
What this interaction means in plain words
Maraviroc and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat weakly induces CYP3A, increasing maraviroc metabolism.
What to do
Monitor HIV viral load and virologic response during and after tecovirimat therapy; consider maraviroc levels where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Maraviroc and Tecovirimat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Tecovirimat?
MediHelp rates the interaction as moderate. Maraviroc and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat may reduce maraviroc exposure, possibly weakening antiretroviral control. The effect is predicted from enzyme induction rather than established clinically.
How serious is the interaction between Maraviroc and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and virologic response during and after tecovirimat therapy; consider maraviroc levels where available.
What other medicines interact with Tecovirimat?
MediHelp also lists interactions of Tecovirimat with, for example, Bosentan, Cyclosporin, Darunavir. The full list is on the Tecovirimat page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
