Drug interactions
Ethinyl estradiol-levonorgestrel + Voriconazole
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises plasma concentrations of ethinyl estradiol and also of levonorgestrel-type progestins, and the contraceptive can in turn modestly raise voriconazole levels. Increased estrogen exposure may cause nausea, headache, breast tenderness and a greater thrombotic burden, and azole-related adverse effects may also be more frequent.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 (and CYP2C19), reducing the metabolism of the hormones, with possible reciprocal effects on voriconazole.
What to do
Monitor for estrogen-related adverse effects such as nausea, headache and hypertension, and for voriconazole toxicity including visual disturbance and hepatotoxicity. Consider a lower-estrogen or non-hormonal method if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Voriconazole?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises plasma concentrations of ethinyl estradiol and also of levonorgestrel-type progestins, and the contraceptive can in turn modestly raise voriconazole levels. Increased estrogen exposure may cause nausea, headache, breast tenderness and a greater thrombotic burden, and azole-related adverse effects may also be more frequent.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects such as nausea, headache and hypertension, and for voriconazole toxicity including visual disturbance and hepatotoxicity. Consider a lower-estrogen or non-hormonal method if these occur.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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