Drug interactions
Ethinyl estradiol-norgestimate + Etravirine
Severity: Moderate
Ethinyl estradiol-norgestimate and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer but also affects other enzymes, and it has been reported to alter ethinyl estradiol exposure. Contraceptive reliability may be uncertain and progestin exposure may be reduced.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 and CYP2C enzymes, altering the metabolism of ethinyl estradiol and progestins.
What to do
Recommend an additional or alternative non-hormonal contraceptive method during etravirine therapy. Monitor for breakthrough bleeding as a sign of reduced hormone exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Etravirine?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer but also affects other enzymes, and it has been reported to alter ethinyl estradiol exposure. Contraceptive reliability may be uncertain and progestin exposure may be reduced.
How serious is the interaction between Ethinyl estradiol-norgestimate and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional or alternative non-hormonal contraceptive method during etravirine therapy. Monitor for breakthrough bleeding as a sign of reduced hormone exposure.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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