Drug interactions
Ethinyl estradiol-norgestimate + Flibanserin
Severity: Moderate
Ethinyl estradiol-norgestimate and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin exposure may rise with CYP3A4 inhibitors, and oral contraceptives are weak inhibitors. Increased flibanserin levels can cause more hypotension, syncope and sedation. Labeling notes that contraceptives were used in the clinical program, and the effect is modest.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Flibanserin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4 by ethinyl estradiol reduces flibanserin metabolism.
What to do
Counsel on dizziness, sedation and avoiding alcohol; monitor for hypotension or syncope, especially if other weak CYP3A4 inhibitors are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Flibanserin?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin exposure may rise with CYP3A4 inhibitors, and oral contraceptives are weak inhibitors. Increased flibanserin levels can cause more hypotension, syncope and sedation. Labeling notes that contraceptives were used in the clinical program, and the effect is modest.
How serious is the interaction between Ethinyl estradiol-norgestimate and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on dizziness, sedation and avoiding alcohol; monitor for hypotension or syncope, especially if other weak CYP3A4 inhibitors are also used.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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