Drug interactions
Ethinyl estradiol-norgestimate + Fluvoxamine
Severity: Minor
Ethinyl estradiol-norgestimate and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP1A2 and CYP3A4 and may raise ethinyl estradiol levels. The legacy direction is reversed, since ethinyl estradiol is not meaningfully raising fluvoxamine. Increased estrogenic effects are possible.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP-mediated hepatic metabolism of ethinyl estradiol.
What to do
Monitor for estrogenic adverse effects and blood pressure; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Fluvoxamine?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine inhibits CYP1A2 and CYP3A4 and may raise ethinyl estradiol levels. The legacy direction is reversed, since ethinyl estradiol is not meaningfully raising fluvoxamine. Increased estrogenic effects are possible.
How serious is the interaction between Ethinyl estradiol-norgestimate and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and blood pressure; no routine dose change is needed.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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