Drug interactions
Ethinyl estradiol-norgestimate + Iloperidone
Severity: Minor
Ethinyl estradiol-norgestimate and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has been described as a weak time-dependent CYP3A inhibitor in vitro, so it could slightly raise ethinyl estradiol levels. Clinical significance is expected to be small.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4 by iloperidone reduces ethinyl estradiol clearance.
What to do
No dose adjustment is usually needed. Monitor for increased estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Iloperidone?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone has been described as a weak time-dependent CYP3A inhibitor in vitro, so it could slightly raise ethinyl estradiol levels. Clinical significance is expected to be small.
How serious is the interaction between Ethinyl estradiol-norgestimate and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for increased estrogenic adverse effects.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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