Drug interactions
Ethinyl estradiol-norgestimate + Itraconazole
Severity: Moderate
Ethinyl estradiol-norgestimate and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole, a strong CYP3A4 inhibitor, may raise ethinyl estradiol and progestin concentrations. This could increase estrogenic and progestogenic adverse effects, though contraceptive efficacy is not reduced.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ethinyl estradiol and norgestimate metabolites.
What to do
Monitor for estrogenic effects such as nausea, breast tenderness, hypertension and thrombosis risk factors during prolonged itraconazole therapy; reassess the contraceptive if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Itraconazole?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole, a strong CYP3A4 inhibitor, may raise ethinyl estradiol and progestin concentrations. This could increase estrogenic and progestogenic adverse effects, though contraceptive efficacy is not reduced.
How serious is the interaction between Ethinyl estradiol-norgestimate and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic effects such as nausea, breast tenderness, hypertension and thrombosis risk factors during prolonged itraconazole therapy; reassess the contraceptive if adverse effects develop.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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