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Drug interactions

Ethinyl estradiol-norgestimate + Liraglutide

Severity: Minor

Ethinyl estradiol-norgestimate and Liraglutide: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Combined hormonal contraceptives may slightly impair glucose tolerance, which could modestly oppose liraglutide's glucose-lowering effect. Liraglutide can also cause vomiting or diarrhea that may reduce oral contraceptive absorption.

What this interaction means in plain words

Ethinyl estradiol-norgestimate and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Ethinyl estradiol-norgestimate belongs to Endocrine; Liraglutide belongs to Endocrine.

Evidence level: Low

Why it happens

Hormone-related reduction in insulin sensitivity opposes the antihyperglycemic action of liraglutide.

What to do

Monitor glycemic control when starting or stopping the contraceptive, and advise backup contraception if severe vomiting or diarrhea occurs.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Ethinyl estradiol-norgestimate with Liraglutide?

MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combined hormonal contraceptives may slightly impair glucose tolerance, which could modestly oppose liraglutide's glucose-lowering effect. Liraglutide can also cause vomiting or diarrhea that may reduce oral contraceptive absorption.

How serious is the interaction between Ethinyl estradiol-norgestimate and Liraglutide?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting or stopping the contraceptive, and advise backup contraception if severe vomiting or diarrhea occurs.

What other medicines interact with Ethinyl estradiol-norgestimate?

MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.

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