Drug interactions
Ethinyl estradiol-norgestimate + Lomitapide
Severity: Moderate
Ethinyl estradiol-norgestimate and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives containing ethinyl estradiol are weak CYP3A4 inhibitors and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal effects. Lomitapide itself may cause hepatic steatosis and elevated transaminases.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Lomitapide belongs to Cardiovascular.
Why it happens
Ethinyl estradiol weakly inhibits CYP3A4, reducing the first-pass metabolism of lomitapide.
What to do
Limit the lomitapide dose according to labeling when used with weak CYP3A4 inhibitors, and monitor liver enzymes. Adjust the dose if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Lomitapide?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives containing ethinyl estradiol are weak CYP3A4 inhibitors and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal effects. Lomitapide itself may cause hepatic steatosis and elevated transaminases.
How serious is the interaction between Ethinyl estradiol-norgestimate and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose according to labeling when used with weak CYP3A4 inhibitors, and monitor liver enzymes. Adjust the dose if transaminases rise.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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