Drug interactions
Ethinyl estradiol-norgestimate + Midazolam
Severity: Minor
Ethinyl estradiol-norgestimate and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives may slightly reduce the clearance of oxidatively metabolised benzodiazepines such as midazolam. This can result in increased or prolonged sedation, though the effect is generally modest.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Midazolam belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated midazolam metabolism by ethinyl estradiol.
What to do
Monitor sedation level and titrate midazolam to effect; no routine dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Midazolam?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptives may slightly reduce the clearance of oxidatively metabolised benzodiazepines such as midazolam. This can result in increased or prolonged sedation, though the effect is generally modest.
How serious is the interaction between Ethinyl estradiol-norgestimate and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and titrate midazolam to effect; no routine dose change is usually required.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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