Drug interactions
Ethinyl estradiol-norgestimate + Tizanidine
Severity: Moderate
Ethinyl estradiol-norgestimate and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives reduce tizanidine clearance by about half in pharmacokinetic data, which can increase sedation, hypotension and bradycardia. The effect is usually manageable but may be noticeable in sensitive patients.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Tizanidine belongs to Musculoskeletal.
Why it happens
Ethinyl estradiol likely reduces CYP1A2-mediated clearance of tizanidine.
What to do
Start tizanidine at a low dose and titrate cautiously, monitoring blood pressure, heart rate and sedation. Reduce the dose if drowsiness or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Tizanidine?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives reduce tizanidine clearance by about half in pharmacokinetic data, which can increase sedation, hypotension and bradycardia. The effect is usually manageable but may be noticeable in sensitive patients.
How serious is the interaction between Ethinyl estradiol-norgestimate and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tizanidine at a low dose and titrate cautiously, monitoring blood pressure, heart rate and sedation. Reduce the dose if drowsiness or hypotension occurs.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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