Drug interactions
Ethinylestradiol + Flibanserin
Severity: Moderate
Ethinylestradiol and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives containing ethinylestradiol are weak CYP3A4 inhibitors and modestly raise flibanserin exposure. Flibanserin labeling notes increased exposure in women taking oral contraceptives, with potential for more dizziness, sedation and hypotension.
What this interaction means in plain words
Ethinylestradiol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinylestradiol weakly inhibits CYP3A4, reducing flibanserin clearance.
What to do
Counsel on dizziness, somnolence and syncope, especially if other CYP3A4 inhibitors are also used. Monitor tolerability and reassess if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Flibanserin?
MediHelp rates the interaction as moderate. Ethinylestradiol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives containing ethinylestradiol are weak CYP3A4 inhibitors and modestly raise flibanserin exposure. Flibanserin labeling notes increased exposure in women taking oral contraceptives, with potential for more dizziness, sedation and hypotension.
How serious is the interaction between Ethinylestradiol and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on dizziness, somnolence and syncope, especially if other CYP3A4 inhibitors are also used. Monitor tolerability and reassess if adverse effects occur.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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