Drug interactions
Ethinylestradiol + Fluvoxamine
Severity: Minor
Ethinylestradiol and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is a weak CYP1A2 inhibitor and can modestly raise fluvoxamine concentrations, which are mainly cleared by CYP2D6 and CYP1A2. Fluvoxamine may also affect estrogen metabolism, but the clinical effect on contraception is not established.
What this interaction means in plain words
Ethinylestradiol and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ethinylestradiol weakly inhibits CYP1A2, reducing fluvoxamine clearance.
What to do
No routine adjustment is needed; watch for increased fluvoxamine side effects such as nausea or drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Fluvoxamine?
MediHelp rates the interaction as minor. Ethinylestradiol and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol is a weak CYP1A2 inhibitor and can modestly raise fluvoxamine concentrations, which are mainly cleared by CYP2D6 and CYP1A2. Fluvoxamine may also affect estrogen metabolism, but the clinical effect on contraception is not established.
How serious is the interaction between Ethinylestradiol and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for increased fluvoxamine side effects such as nausea or drowsiness.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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