Drug interactions
Ethinylestradiol + Midazolam
Severity: Minor
Ethinylestradiol and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol may modestly reduce the oxidative clearance of midazolam, leading to somewhat higher drug exposure and prolonged sedation. The effect is generally small and variable.
What this interaction means in plain words
Ethinylestradiol and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of midazolam by ethinylestradiol.
What to do
No dose change is usually needed; watch for prolonged sedation after midazolam in patients taking estrogen-containing contraceptives and titrate to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Midazolam?
MediHelp rates the interaction as minor. Ethinylestradiol and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol may modestly reduce the oxidative clearance of midazolam, leading to somewhat higher drug exposure and prolonged sedation. The effect is generally small and variable.
How serious is the interaction between Ethinylestradiol and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for prolonged sedation after midazolam in patients taking estrogen-containing contraceptives and titrate to effect.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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