Drug interactions
Ethinylestradiol + Mycophenolate mofetil
Severity: Major
Ethinylestradiol and Mycophenolate mofetil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate labeling notes that hormonal contraceptive efficacy may be reduced, with small changes in progestin exposure observed. Because mycophenolate is teratogenic, any loss of contraceptive reliability is clinically important.
What this interaction means in plain words
Ethinylestradiol and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mechanism is not established; pharmacokinetic changes in contraceptive hormones have been observed.
What to do
Advise an additional barrier contraceptive method alongside hormonal contraception, and follow pregnancy prevention requirements for mycophenolate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Mycophenolate mofetil?
MediHelp rates the interaction as major. Ethinylestradiol and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mycophenolate labeling notes that hormonal contraceptive efficacy may be reduced, with small changes in progestin exposure observed. Because mycophenolate is teratogenic, any loss of contraceptive reliability is clinically important.
How serious is the interaction between Ethinylestradiol and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional barrier contraceptive method alongside hormonal contraception, and follow pregnancy prevention requirements for mycophenolate.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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