Drug interactions
Ethinylestradiol + Ribociclib
Severity: Moderate
Ethinylestradiol and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is metabolized by CYP3A4, so ribociclib may raise its exposure. Estrogen-containing products are generally avoided in hormone-receptor-positive breast cancer, and non-hormonal contraception is advised during ribociclib treatment.
What this interaction means in plain words
Ethinylestradiol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing ethinylestradiol clearance.
What to do
Use effective non-hormonal contraception rather than estrogen-containing products during ribociclib therapy. If ethinylestradiol is used, monitor for estrogenic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Ribociclib?
MediHelp rates the interaction as moderate. Ethinylestradiol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinylestradiol is metabolized by CYP3A4, so ribociclib may raise its exposure. Estrogen-containing products are generally avoided in hormone-receptor-positive breast cancer, and non-hormonal contraception is advised during ribociclib treatment.
How serious is the interaction between Ethinylestradiol and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use effective non-hormonal contraception rather than estrogen-containing products during ribociclib therapy. If ethinylestradiol is used, monitor for estrogenic adverse effects.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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