Drug interactions
Ethosuximide + Etravirine
Severity: Moderate
Ethosuximide and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower ethosuximide levels. Seizure control could be reduced.
What this interaction means in plain words
Ethosuximide and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 and increases ethosuximide clearance.
What to do
Monitor seizure control and ethosuximide levels after starting or stopping etravirine. Increase the ethosuximide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Ethosuximide with Etravirine?
MediHelp rates the interaction as moderate. Ethosuximide and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower ethosuximide levels. Seizure control could be reduced.
How serious is the interaction between Ethosuximide and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and ethosuximide levels after starting or stopping etravirine. Increase the ethosuximide dose if needed.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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