Drug interactions
Ethosuximide + Iloperidone
Severity: Moderate
Ethosuximide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has some CYP3A inhibiting effect and may raise ethosuximide levels. Both drugs can also cause sedation, so drowsiness may increase.
What this interaction means in plain words
Ethosuximide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by iloperidone plus additive CNS depression.
What to do
Monitor for sedation and other ethosuximide adverse effects. Check serum levels and reduce the dose if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Ethosuximide with Iloperidone?
MediHelp rates the interaction as moderate. Ethosuximide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has some CYP3A inhibiting effect and may raise ethosuximide levels. Both drugs can also cause sedation, so drowsiness may increase.
How serious is the interaction between Ethosuximide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and other ethosuximide adverse effects. Check serum levels and reduce the dose if toxicity is suspected.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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