Drug interactions
Ethosuximide + Letermovir
Severity: Moderate
Ethosuximide and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir moderately inhibits CYP3A4 and may increase exposure to ethosuximide. This could lead to concentration-related adverse effects including sedation and gastrointestinal upset.
What this interaction means in plain words
Ethosuximide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by letermovir reducing ethosuximide clearance.
What to do
Monitor clinical response and ethosuximide adverse effects; measure serum levels and reduce the dose if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Ethosuximide with Letermovir?
MediHelp rates the interaction as moderate. Ethosuximide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir moderately inhibits CYP3A4 and may increase exposure to ethosuximide. This could lead to concentration-related adverse effects including sedation and gastrointestinal upset.
How serious is the interaction between Ethosuximide and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and ethosuximide adverse effects; measure serum levels and reduce the dose if toxicity is suspected.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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