Drug interactions
Ethosuximide + Tipranavir
Severity: Moderate
Ethosuximide and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, a strong CYP3A4 inhibitor, which may raise ethosuximide concentrations. This could cause sedation, gastrointestinal upset and ataxia. The net effect of tipranavir/ritonavir on CYP3A4 can be complex, because tipranavir also has inducing properties.
What this interaction means in plain words
Ethosuximide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir inhibits CYP3A4, which contributes to ethosuximide metabolism, reducing its clearance.
What to do
Monitor for ethosuximide toxicity after starting tipranavir/ritonavir. Consider checking serum levels and reducing the dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethosuximide and Tipranavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Ethosuximide with Tipranavir?
MediHelp rates the interaction as moderate. Ethosuximide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is given with ritonavir, a strong CYP3A4 inhibitor, which may raise ethosuximide concentrations. This could cause sedation, gastrointestinal upset and ataxia. The net effect of tipranavir/ritonavir on CYP3A4 can be complex, because tipranavir also has inducing properties.
How serious is the interaction between Ethosuximide and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide toxicity after starting tipranavir/ritonavir. Consider checking serum levels and reducing the dose if adverse effects appear.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
