Drug interactions
Ethosuximide + Voriconazole
Severity: Moderate
Ethosuximide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise ethosuximide concentrations since ethosuximide is partly metabolized by CYP3A4. Excess levels may cause drowsiness, nausea, ataxia, and dizziness.
What this interaction means in plain words
Ethosuximide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, reducing the hepatic metabolism of ethosuximide.
What to do
Monitor for ethosuximide toxicity and consider checking serum levels when voriconazole is started or stopped. Reduce the ethosuximide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Frequently asked questions
Can I take Ethosuximide with Voriconazole?
MediHelp rates the interaction as moderate. Ethosuximide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise ethosuximide concentrations since ethosuximide is partly metabolized by CYP3A4. Excess levels may cause drowsiness, nausea, ataxia, and dizziness.
How serious is the interaction between Ethosuximide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide toxicity and consider checking serum levels when voriconazole is started or stopped. Reduce the ethosuximide dose if needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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