Drug interactions
Ethotoin + Fluvoxamine
Severity: Moderate
Ethotoin and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethotoin is metabolized by hepatic enzymes, and fluvoxamine inhibits CYP2C9 and CYP2C19 and could raise its levels. The effect is predicted from related hydantoin interactions, since phenytoin levels are known to rise with fluvoxamine, but it has not been well studied with ethotoin.
What this interaction means in plain words
Ethotoin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluvoxamine inhibits CYP2C9/2C19 and may decrease hydantoin clearance.
What to do
Monitor for signs of ethotoin toxicity such as ataxia, nystagmus and sedation, and consider dose reduction or drug level monitoring if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Ethotoin with Fluvoxamine?
MediHelp rates the interaction as moderate. Ethotoin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethotoin is metabolized by hepatic enzymes, and fluvoxamine inhibits CYP2C9 and CYP2C19 and could raise its levels. The effect is predicted from related hydantoin interactions, since phenytoin levels are known to rise with fluvoxamine, but it has not been well studied with ethotoin.
How serious is the interaction between Ethotoin and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of ethotoin toxicity such as ataxia, nystagmus and sedation, and consider dose reduction or drug level monitoring if available.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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