Drug interactions
Ethotoin + Mebendazole
Severity: Moderate
Ethotoin and Mebendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydantoin anticonvulsants can lower mebendazole concentrations, potentially reducing efficacy against systemic helminth infections. The effect is best documented with phenytoin and carbamazepine, and extrapolated for ethotoin.
What this interaction means in plain words
Ethotoin and Mebendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by the hydantoin increases hepatic metabolism of mebendazole.
What to do
For systemic infections such as hydatid disease, monitor clinical response or drug levels and consider a higher mebendazole dose or alternative agent; no action is usually needed for intestinal infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mebendazole
- Deferiprone + Mebendazole Major
- Mebendazole + Metronidazole Major
- Acalabrutinib + Mebendazole Moderate
- Carbamazepine + Mebendazole Moderate
- Fosphenytoin + Mebendazole Moderate
- Mebendazole + Phenytoin Moderate
Frequently asked questions
Can I take Ethotoin with Mebendazole?
MediHelp rates the interaction as moderate. Ethotoin and Mebendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydantoin anticonvulsants can lower mebendazole concentrations, potentially reducing efficacy against systemic helminth infections. The effect is best documented with phenytoin and carbamazepine, and extrapolated for ethotoin.
How serious is the interaction between Ethotoin and Mebendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For systemic infections such as hydatid disease, monitor clinical response or drug levels and consider a higher mebendazole dose or alternative agent; no action is usually needed for intestinal infections.
What other medicines interact with Mebendazole?
MediHelp also lists interactions of Mebendazole with, for example, Deferiprone, Metronidazole, Acalabrutinib. The full list is on the Mebendazole page.
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